Watch 49ers' Marcell Harris force Lamar Jackson's first fumble of year

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But the double-threat quarterback was solid when it counted. Jackson's rushing yards ranks ninth in the NFL.

Under intense pressure, Chuck Clark stripped the ball from Garoppolo and Brandon Williams recovered at San Francisco's 23-yard line. In a game with Lamar Jackson, Mark Ingram and Tevin Coleman starting, it was Mostert who was the runaway train.

On the ensuing drive, the 49ers got the Ravens to fourth down yet again, but Jackson converted this time, on a three-yard quarterback sneak. Jackson was still effective as a runner, but the 49ers' ultra-athletic defensive front proved the Ravens' offense is not invincible against. The San Francisco 49ers have the number one defense in the National Football League and they have 10 wins on their resume.

The interconference titanic pits the top team in the NFC (the 10-1 49ers) against the hottest team in the AFC (the 9-2 Ravens) in a game that won't guarantee anything for the victor, but figures to create a potential problem for the loser.

A 33-yard touchdown pass from Garoppolo to Deebo Samuel concluded San Francisco's first drive and made the 49ers the first team to score in the first quarter against Baltimore since the Bengals on October 13. Given the magnitude of the contest, much of the country will receive the 49ers-Ravens game on their local FOX affiliate.

Baltimore tied it with a 20-yard pass from Jackson to Andrews after Garoppolo lost the ball while being sacked.

The 49ers rank second in the National Football League in total rushes (371), rushing yards (1,602) and rushing yards per game (145.6).

During Baltimore's second touchdown drive, Jackson put a move on K'Waun Williams that caused the cornerback to stagger to his right and fall down as the quarterback blew past him during a 7-yard run. Head coach Kyle Shanahan and company were ecstatic to have tight end George Kittle back after missing two games with an injury.

At 5/1, the 49ers are the bookmakers' third favorite, marginally ahead of the 11/2 New Orleans Saints, who became the first team to book a playoff spot this season with a 26-18 road win over the Atlanta Falcons on Thanksgiving Day.

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