"He won't be ready for the derby", Guardiola told reporters.
The 34-year-old Brazil midfielder, who has been deployed as a centre-back this season, sees his current deal expire in June 2020.
Guardiola says it is pointless for his team to worry about the gap at the top of the table, placing a focus on taking each game as it comes in order to stay in the title picture for as long as possible.
Although Fernandinho has spent all his career as a midfielder - including more than six years and 250 appearances at City - Guardiola reacted tersely when he was asked why the Brazilian was used in defence more often than Stones and Otamendi, who cost a combined £79.5m.
"Since last season, when Brendan Rodgers took over the team, immediately they changed the way they play and they [got] the results". All we can do is win every game, it's going to be a big challenge for us.
"Last year was quite similar when [Liverpool] had a similar lead but we still have time this year to recover, to catch them and to again try to win the Premier League, so we hope we can do that".
"If we can not do it in summer, we can not do it in January".
Kompany left in the close season, while Silva will finish his City career at the end of the current campaign.
"They were better than the other ones, we played good, especially in the second half".
"This group is extraordinary, the group is incredible".
Guardiola has urged his players to forget about the teams above them ahead of the clash with the Clarets. "Buying two or three players is not rebuilding; it's just substituting positions".
Manchester City's star center back has been missing since August 31 with a serious knee injury he suffered against Brighton, which then required surgery. Sometimes the club wants to try to do the best but sometimes we can not.
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