Pulisic, who has now scored five goals in Chelsea's last three Premier League games, wrapped up the victory with his 79th-minute strike, heading in after substitute Michy Batshuayi's blocked shot bounced up for the United States worldwide.
Chelsea have been in fine form this season in the Premier League and next up they welcome Crystal Palace at Stamford Bridge on Saturday. The victory brought about a milestone for Chelsea boss Frank Lampard.
Ross Barkley is also close to a return from injury but the England worldwide is still not a 100 per cent fit meaning Mateo Kovacic will be partnered by N'Golo Kante in central midfield vs the Eagles.
Antonio Rudiger has been ruled out for at least another three weeks due to an on-going groin injury while Ruben Loftus-Cheek remains on the sidelines with a serious Achilles problem.
Kepa made a fantastic last-minute save last time around in the Premier League against Watford, and was kept busy in the Chelsea goal against Ajax. We could see one of the two be replaced by Christensen in the Chelsea lineup.
There remains the temptation to start Reece James and potentially field Azpilicueta at left-back but Lampard may continue to stick with Emerson, who has impressed despite his injury concerns this term.
The Eagles will be looking to bounce back from their defeat at home to Leicester last weekend, in which the absence of one or two stars hampered them against Brendan Rodgers' men.
'In the first half we started well, then allowed our tempo to drop, but when we came out in the second half with the intent that we did, we won the game relatively comfortably - a nice, solid win with a clean sheet.
If Mount can not make himself fit in time then it will be one of the forward who is likely to play in the attacking midfielder's role. Mateo Kovacic had a good game against Ajax, and he should start in midfield again.