Looking past his first two seasons when he started just 13 games, the strong-armed 31-year-old gunslinger has been as tough as they come in the NFL.
Now, a report from ESPN's Adam Schefter says Stafford will likely be a game-time decision on Sunday.
Matthew Stafford was listed as questionable for the Detroit Lions, but his status seems to be determined already.
The reasons, according to ESPN, were fractured bones in Stafford's back, an injury that reportedly dates back to a year ago. Got to the stadium this morning, met with the doctors and wasn't medically cleared to play today so he's deactivated.
It's unclear how Stafford incurred the injury, though he did take a hard shot against the Raiders in a last-second loss last Sunday.
When asked about his injured back on Wednesday, Stafford declared it was "fine".
Ryan's streak of 154 consecutive starts came to an end last month because of an ankle injury.
In 2016, Stafford tore ligaments in the middle finger on his right (throwing) hand during a 20-17 win over the Bears and stayed on the field to lead the Lions' comeback. "I'm not really anxious about it".
Stafford is now considered week-to-week with an injury that one source said could sideline him for "this week or 3 weeks".