The South Dakota Department of Health reports the number of cases jumped from six cases at the end of September to 11 cases as of Thursday.
The deaths occurred in adults and were confirmed today by the Centers for Disease Control and Prevention (CDC)."These deaths are heartbreaking", said State Health Commissioner Kris Box, M.D. in is now investigating 75 cases of severe lung injury linked to vaping, a total that has doubled in the past month.
They're using the acronym, EVALI, short for "E-cigarettes or Vaping product use Associated Lung Injury".
The guidance comes after MI announced the state's first death from vaping-related lung injury last week.
About 70% of the 1,043 patients, on whom data is available, are male, with 15% below 18 years of age, according to the CDC.
The number of confirmed and probable lung illnesses tied to vaping had also climbed to 1,299.
In Utah, health officials said the victim was under 30, and had also "vaped THC prior to their death".
CDC and MDHHS recommend that persons should not use e-cigarette or vaping products that contain tetrahydrocannabinol (THC).
Last week, the FDA warned consumers to stop using THC vaping products as investigations into vaping-related lung injuries and deaths continue.
Washington state Governor Jay Inslee has urged state agencies to ban flavoured and cannabis-derived vaping products.
Individuals who do not now use tobacco products should not start using e-cigarette or vaping products. The majority of the cases have occurred among individuals ages 16-29.
The CDC says people should consider refraining from vaping, especially with products including THC.
In the USA, some states, including New York, Michigan and Rhode Island, have banned the sale of flavoured e-cigarettes, while MA has gone a step further by imposing a four-month ban on all vaping products.