Frank Lampard has backed Tammy Abraham to score regularly for England after his impressive start to the season for Chelsea was rewarded with a call-up to the national squad.
Tottenham's Dele Alli failed to make the cut, as Mason Mount was named ahead of him.
Neither Manchester City's Kyle Walker nor Manchester United's Aaron Wan-Bissaka have been picked - the latter has been unwell of late - with Southgate opting for Trent Alexander-Arnold of Liverpool and Kieran Trippier of Atletico Madrid as his right-backs.
But Southgate also knows how important finishing the campaign in November with a ideal record will be for seeding in the draw and is very much focused on each game at a time.
Shining Chelsea stars Tammy Abraham and Fikayo Tomori have received their first senior call up to the England squad for the upcoming Euro 2020 qualifiers. "The season hasn't quite got going for him yet but we're expecting him to challenge in the coming months".
"I think Jesse has had a hard time too". You only have to look at the number of goals we scored and the number of chances we created and the way our attacking play was.
Their situations are in stark contrast to just six months ago, when both players were out on loan in the Championship at Aston Villa and Derby County respectively.
Having made a 100% winning start to the Euro 2020 qualifying campaign, England could even secure their place at the tournament this month if they win both games.
Centre-back Tomori, 21, is also eligible to represent Nigeria and Canada at the worldwide level.
"I retain huge faith in Jesse because he's a player who's always played well for us, he's never let us down".
After playing in five of England's seven matches at the 2018 World Cup, Alli's season was hampered by injuries in 2018-19 and his problems coincided with Tottenham's dip in form in February. "Now he's in a tough period but we need him".