National police spokesman Dedi Prasetyo said Wiranto was stabbed in the abdomen.
Indonesia Chief Security Minister Wiranto delivers a speech during a meeting between former militants and victims in Jakarta, Indonesia, February 28, 2018.
President Joko Widodo and Vice President Jusuf Kalla has visited Wiranto at the Gatot Subroto Army Hospital.
The 51-year-old alleged attacker and a 20-year-old female companion were arrested.
"Wiranto was injured at the front part of his body, (and) head of district police Commissioner Adrianto was wounded at the back of his body and (a resident) Aji Fual was also injured", he said.
ANTARA learned that a helicopter has been on standby at the Pandeglang Square for evacuating Wiranto to Jakarta.
The assault happened after the senior minister attended the inauguration of a university building in Sindanghayu village, Saketi subdistrict, local news media bantennews.co.id is reporting.
Mr Prasetyo also said the attacker injured a police chief who was about to greet Wiranto as the Minister alighted from a auto, along with a villager. Police had arrested a man and a woman they suspected were a couple, and seized sharp weapons they were carrying, including knives and a pair of scissors.
Police said Alamsyah had been "exposed to ISIL radicalism", referring to the Islamic State group, without elaborating.
It was not immediately clear if either were members of one of the dozens of radical groups that have pledged loyalty to the Islamic State group in Indonesia, the world's biggest Muslim majority nation.
Investigations are underway to find out the groups that the two attackers belong to, he told local TV One.
"While very serious, this attempt should not be over dramatized".
Wiranto was named security minister in 2016 and wields significant power in Indonesian politics.
Wiranto ran unsuccessfully for president in 2004 and for the vice-presidency in 2009.