After the two traded more breaks in the first set, Williams landed the telling blow to win the opener 6-4.
The fact that Murray is even playing tennis once again is a wonder in itself, after announcing that he would most likely retire following the massive surgery on his hip. Konta responded: "Is that in your professional tennis opinion?"
The British number one deserved huge credit for getting to the last eight at a second consecutive grand slam but, as in the semi-finals of the French Open, when the favourite's tag was on her, Konta was found wanting. But then Riske broke late in the second set to drive towards levelling up the fixture. She won the match.
The tiebreak summed up her display.
Last year, Williams was fined $17,000 after smashing her racket and arguing with match official Carlos Ramos during her straight-set finals loss to Naomi Osaka of Japan.
"It's a long, arduous road, " Williams said.
"The pressure is off him, I don't feel like there is any pressure on him at all, it has just been good fun to see him playing with no pain". Finally I realized that there was only one way for me to move forward. I will try to use them as much as I can.
"I don't think you need to pick on me in a harsh way", she said.
SERENA Williams of the U.S. celebrates beating compatriot Alison Riske in the quarter-final.
Serena Williams reached her 12th Wimbledon semifinal with a gritty three-set victory against fellow American Alison Riske on Centre Court Tuesday.
The end was nigh when Konta blazed a forehand drive volley over the baseline in another moment reminiscent of the French Open to drop serve again in the sixth game, and a final error sealed her fate.
The 33-year-old Czech - who has ousted four seeds on her run to the semi-finals - lasthad been mulling over retiring but may have a rethink after she came back from 4-1 down in the first set to dominate the match with some delightful strokeplay.
Riske converted all five of her break points while Serena succeeded with just six of her 16 opportunities. For Halep it is a second semi-final here, five years after her first, while Svitolina is the first Ukrainian woman to make a grand slam last four.
However, Williams served it out with an ace to seal her 97th win at Wimbledon and will play Czech veteran Barbora Strycova, who beat Britain's Johanna Konta 7-6 (7-5), 6-1, for a place in the final. As a bonus, Mair is including two best bets for the other women's semifinal: Simona Halep vs. Elina Svitolina. In the tiebreaker, she converted her first set point with a forehand victor.