Reyes won 21 caps for Spain between 2003 and 2006, and scooped the UEFA Cup and Europa League a combined five times in a decorated club career.
One of Sevilla's greatest homegrown talents, Jose Antonio Reyes, has died at the age of 35 after a traffic accident.
Sevilla, where Reyes played in two separate spells, the second of which included a succession of Europa League triumphs, tweeted: "We couldn't be announcing any worse news".
You only need to look at the reaction to today's tragic news to see how highly regarded Reyes was in the handsome game by both former teammates, rivals and simply admirers.
He helped Sevilla win the Spanish second division in his first stint at the club.
Tributes have been pouring in from all over the world, including his former clubs, managers and teammates.
Jose Antonio Reyes has died in a vehicle crash in Spain.
Rafa sending "heartfelt condolences" to Reyes" family and friends, whilst Ayoze Perez sends "a huge hug to his family'.
"I'm devastated to hear the sad news about Jose Antonio Reyes", read Henry's Tweet.
Spanish newspaper Marca reported that the accident happened in his hometown Utrera, a province of Seville, on Saturday morning. "He will remain forever in our hearts".
Spain captain Sergio Ramos, a former team mate of Reyes at Sevilla said on social media "I'm broken, destroyed, I have no words".
Reyes also played in the Champions League final against Barcelona in 2006.