She said that Canadian public and the global community should put political pressure on Ottawa to "do something and to actually investigate state actors who are complicit or directly involved in the murders, exploitation and disappearances of indigenous women and girls".
Evelyne Youngchief, a survivor of violence who works on the front lines on the Downtown Eastside of Vancouver, said Monday the report may offer closure to some, but not her.
Independent MP Jody Wilson-Raybould, who was Canada's first Indigenous justice minister when the inquiry was launched, said in a recent interview that she anticipates the report will raise the awareness about the ongoing tragedy.
The report also strongly focuses on the need for actors in the justice system and in police services to acknowledge that the historical and current relationship with Indigenous women, girls, and two-spirit people has been largely defined by "colonialism, racism, bias, discrimination, and fundamental cultural and societal differences".
Minister of Employment, Workforce Development, and Labour, Patty Hajdu, said the action plan has to have concrete steps to build on the work already being done by the government.
"I hope that knowing these truths will contribute to a better understanding of the real lives of Indigenous people and the violations of their human and Indigenous rights when they were targeted for violence".
The report, which was prepared over the course of 40 years, is long-awaited in the country, which is home to 1.6 million people with First Nations heritage.
"Time and again, we have heard of their disappearance, violence, or even death being labelled low priority or ignored", Mr Trudeau said.
Commissioner Qajaq Robinson said Monday that the process had tested her to her core as a non-Indigenous person, struggling to come to terms with her "role in Canada's genocide".
"In order to move forward and to healing, there has to be an acknowledgment of the harm that has happened".
The recommendations - framed in the report as "calls for justice" - include developing an effective response to human trafficking cases and sexual exploitation and violence, including in the sex industry. "And that is why our government has not run away from the fact that systemic racism does exists in this country".
"Shame, guilt, denial, that urge to say, 'No, no, no, that's not what this is, ' " she said.
McGuire-Cyrette said referring to the experiences of Indigenous women, girls, and 2SLGBTQQIA people as genocide is appropriate and representative of what Indigenous people have experienced throughout history. It is part of colonization. It is easily overlooked amid the pages of other crucial findings and recommendations, but contains a thread we may hear more of in the coming months. "Colonization directly attacked Indigenous women specifically through pieces of legislation that is still in place today".
"But I felt like I was being a voice for my mom, who can't speak for herself, so it felt really nice to be able to do something nice for her", said Evans-Harlick.
McGuire-Cyrett added Trudeau needs to stick to his promise and ONWA will hold him to his commitment, along with future governments regarding the importance of this report.
A Royal Canadian Mounted Police report before the inquiry was formed found that while Indigenous women represented about 4.3 per cent of the total female population, they accounted for 16 per cent of all female homicide victims. "That's all we can ask for".