Jurgen Klopp's men won 3-1 in the Allianz Arena on Wednesday to ensure that they will be in the hat for the quarter-final draw on Friday.
Two English sides met in last season's Champions League, of course, when Liverpool eliminated Manchester City in the quarter-final stage.
Although some pointed out that each of the teams are managed by different nationalities - with Argentinian Mauricio Pochettino at Spurs, Norway's Ole Gunnar Solskjaer at United, Germany's Jurgen Klopp at Liverpool, and Spain's Pep Guardiola at City - and not to mention a mass of foreign players in the ranks.
"I would like English teams to play against each other, without any kind of preference", the former Chelsea and United coach told Russian programmeRT.
Whether he was joking or not, it's fair to suggest that Juventus knew exactly what they getting when they signed Ronaldo from Real Madrid last summer.
Top of Group F and produced commanding victory over Schalke in the Round of 16, winning the second leg 7-0 for 10-2 on aggregate.
Messi, whose brilliance was key to Guardiola's two Champions League triumphs with Barcelona, is just as unsafe as Ronaldo and it will be intriguing to see whether any of England's four clubs can find a way to overcome the game's two modern greats.
This means that the chances are there will be at least one all English match during the next round of games in Europe's elite competition, as half of the teams remaining are from the Premier League. At this point of the competition teams from the same country can now face each other.
They have also played twice in European knockout stages and, while Porto eliminated the Blaugrana in 1972/73, the 1985/86 tie had the opposite result. They have undoubtedly got the quality and the confidence at the moment.