Last year's beaten finalists Liverpool received arguably the most favourable draw after being paired with Porto, while Manchester United face a daunting tie against Barcelona.
Juan Mata is also still out for Man Utd with a hamstring injury so Mason Greenwood will be hoping to overcome illness to force his way in to Solskjaer's squad if Lukaku is ruled out. United won both and face another hard game against a Wolves team who had the better of them at Old Trafford in September.
But the image summoned by the prospect of Manchester United at the Nou Camp comes from 1999, with their Norwegian striker in his No 20 shirt, sliding on his knees to celebrate the victor, deep in stoppage time, to complete the most astonishing comeback in the final against Bayern Munich.
Manchester United manager Ole Gunner Solskjaer believes his side "can go all the way" in the Champions League after drawing Barcelona in the quarter-final. But while the careers of Lionel Messi and Scott McTominay have few other parallels and Barca will be clear favourites, this United team have big hearts and the kind of spirit that saw the treble won in Camp Nou 20 years ago.
"This means football fans will notice extra patrols at Wolverhampton station throughout the day, and on train services to and from Manchester both before and after the game".
United were originally drawn to play at Barcelona in the first leg, which would have given them the safety net of playing the decisive return at Old Trafford.
Garner made his senior debut as a late substitute against Crystal Palace at Selhurst Park last month and has been included in a number of senior squads by Red Devils interim boss Ole Gunnar Solskjaer over recent weeks. 'I prefer to be away last, like we had against PSG.
'I could not be further away from thinking it's the best draw because it isn't, it is just the draw, ' insisted Klopp.
"You can never be 100 percent sure, but Alexis is such a determined lad..."
The sides will meet three times in 12 days, with a Premier League clash at the Etihad Stadium three days after the second leg. I have a lot of respect for them. We're battling on all fronts. Solskjaer may be tempted to freshen things up in defence though so Eric Bailly could replace Chris Smalling alongside Victor Lindelof in the middle of the back four.