PSG are already without Neymar, who was ruled out with a foot injury, leaving the French side with only Kylian Mbappé as a world-class striking option.
The 31-year-old injured a tendon in his hip after scoring a penalty in Saturday's 1-0 victory over Bordeaux. Last time around, Jose Mourinho was overly obsessed with defense even at home and they eventually got knocked out after a harrowing loss to Sevilla at home, but with Ole in charge, it is expected that defense won't be given any more importance than attack. It's not his job to replace Cavani and Neymar and he can't play all three roles at once.
"When we go into games confident as we are now, in form, we are looking forward to the game. That's really helpful. He has a lot of confidence in us and we're trying to pay him back in kind".
France star Mbappe is therefore likely to be PSG's main hope of ensuring they leave England with at least an away goal to take back to Parc des Princes for the second leg on March 6. "They're the same level as Barcelona and Real Madrid".
But his performance in front of the media on Monday at Old Trafford was a further example of why the 45-year-old is rivalling Mauricio Pochettino and Massimiliano Allegri as a candidate under consideration from the club's owners, the Glazer family, as Mourinho's long-term successor.
"We have a second leg in Paris where we feel very strong and comfortable in the Parc des Princes".
Speculation has persisted over Neymar returning to LaLiga following his world-record switch to PSG in 2017 but Nene feels the 27-year-old is in the flawless place to realise all his ambitions.
"We've given ourselves the best possible opportunity with the way we've gone into this game because we are confident", added the Norwegian. "What else did you think I was going to do?", Mourinho says in a promotional video filmed at an ice hockey rink posted on Twitter by RT Sports.
"We've proven that in the last 10 or 12 games". If there was ever a time to go into big games, it's now.