Along with the rest of the internet, Lewis, 34, was particularly moved by the Dream Crazy advert and threw his support behind Serena and her fellow female athletes.
"She's a woman who is seven months pregnant and she has been pursued and vilified and chased in the same way that Diana was and its history repeating itself", he told a panel discussion in LA earlier in February.
Nike's latest ad "Dream Crazier" addresses society's double standards for women in sport.
In addition to presenting "A Star is Born" during the ceremony, Williams will star in Nike's "Dream Crazier" ad that will also feature the US women's soccer team, Simone Biles, Chloe Kim, Ibtihaj Muhammad and many other barrier-breaking women's sports figures.
If we want to play against men, we're nuts. The advertisement features some of the best women athletes of the world, including gymnast Simone Biles, snowboarder Chloe Kim, fencer Ibtihaj Muhammad, some members of the USA football team, and victor of 23 tennis Grand Slams, Serena Williams - who also narrates the advertisement.
In saluting Lady Gaga's character, Ali, and her journey through the film-a remake of decades of previous versions featuring Judy Garland, Barbra Streisand and other performers-Williams attested to the choices of career and love that many entertainers and sportspersons must make.
'But a woman running a marathon was insane. "When we're too good, there's 'something wrong with us.' And if we get angry, we're 'hysterical, 'irrational, ' or just being 'crazy'".
What Nike and Serena Williams stand for in the "Dream Crazier" ad doesn't just apply to elite athletes. A woman boxing was insane. Show them what insane can do.
"If they wanna call you insane, fine".
Nike is coming for you.