To make matters worse for the current league leaders, they have the first leg of their Champions League tie away from home against Lyon on February 19, meaning that they will have to play seven games throughout February.
Barcelona qualified for the last-four in dramatic fashion, beating Sevilla 6-1 in the second leg - overturning a first-leg 2-0 deficit.
Barcelona director Guillermo Amor said: "Real Madrid are playing well and they will be the Madrid team we always expect - a group of winners that competes for everything, that can give us a scare if we are not ready to work".
Finally, is the captain's participation in the Club World Cup, where he played the full 180 minutes and went on to lift the trophy with Real Madrid for the third consecutive time. We are talking about two teams that have a lot of resources and extraordinary players.
The French forward, who joined the club in 2009, netted twice in the first half to take his Real tally to 209 goals in 446 games, moving ahead of Mexican Hugo Sanchez into sixth place on the club's all-time top scorers list.
Barcelona are now top of the La Liga table, with Real Madrid 10 points behind in third place. They've been involved in 7 finals and won 5 of them.
Barcelona is trying to win a record fifth straight Copa del Rey title.
Betis have added motivation in this year's competition after their own stadium, the Benito Villamarin, was confirmed as the venue for the final on May 25.