Kawhi topscored for the visiting Raptors with 33 points, 4 rebounds and 4 steals, while Serge Ibaka chipped in a double-double of 22 markers and 10 boards.
Cousins season debut came nearly a year after he tore his left Achilles tendon, an injury that took place when he was with the New Orleans Pelicans.
Cousins credited his teammates for making his return "as smooth and easy as possible".
Cousins went out with a bang. He showed the sharp-shooting Warriors his abilities from long range with his first three-pointer less than a minute into the second quarter and hit two more to open the fourth quarter.
Curry scored 14 of Golden State's 29 points in the third, including their final eight for an 81-72 lead. They played without injured Lou Williams, and Danilo Gallinari left with lower back spasms.
The temperamental Cousins left the game at 8:51 of the fourth in what was the quickest foul out of his career.
This could be a start of a lengthy run at the top for the Warriors who defeated the Nuggets 142-111 on Tuesday night.
"We're not going to drink our own Kool-Aid in terms of understanding that just because he's back, it's a totally different team", Curry said.
The difference for the Warriors, as it has been on so many other nights over the years, is that they have Curry. "They hate me. Uh, I think the only guy they really like is Steph (Curry)", Cousins said recently. Lead the season series 2-1.
Clippers: Had just 11 assists.
Damian Lillard scored 24 points while CJ McCollum and Jake Layman added 20 apiece as Portland downed visiting New Orleans. Irving missed the Celtics game on Monday with a sore right quadriceps. Harden has scored at least 30 points in 18 straight games and has reached 40 in nine of the last 12.
"He does so many things well for them", Clippers coach Doc Rivers said. Patrick Beverley earned a technical while on the bench.
In their previous meeting earlier this season the Warriors won at home with a 131-121 score. Coolio performed at halftime.
While a lot of athletes listen to hard-hitting music to pump them up during workouts or before games, Cousins prefers the slow stuff, listening to artists such as Luther Vandross, Babyface and Aretha Franklin.
Clippers: At the San Antonio Spurs on Sunday to begin a four-game trip.