The Uvalde County Sheriff's Office said it received a call from an aviation monitoring center about a possible downed aircraft in northwest Uvalde around midnight.
The couple were students at Sam Houston State University where they were studying agriculture.
Gerald Green Lawrence, the pilot of the Bell 206B helicopter, also died in the 1:47 a.m. crash.
The helicopter had taken off a few kilometres away from the family ranch in Uvalde, Texas, where the ceremony was held.
Later, all that remained on the site was a picture of the couple, their names and the date and place of the wedding.
"Our deepest sympathies and thoughts are with this family at their great loss", it reads.
"These two spent their last day on this earth celebrating with their most cherished loved ones - I believe it truly was the best day of their lives", their photographer and friend, Madi Wagner, wrote on Facebook.
A November 3 wedding date was listed on a website for the Ackerman and Byler nuptials.
Engagement photos posted on the website show Mr Byler in his cowboy hat embracing Ms Ackerman.