The 52-year-old star, who was accepting her Global Icon award, said she was speaking out for "women whose voices have been stifled". She is truly deserving of this award which is an affirmation of how consistent commitment and hard work leads to success.
She is the founder of "She Writes Woman" and "Safe Place", the first 24/7 mental health crisis helpline and the first anonymous women-only mental health support group in Nigeria.
"This win will inspire the younger generations not to stop believing in their dreams and focus on their ambitions".
Cabello was loud in her appreciation of a successful year for the rising stars. She also topped the category for best act. So the award show felt decidedly less crowded than other red carpets with big names. Born in Havana before her family left for Miami, Cabello was discovered on the USA version of X-Factor and formed a part of the group Fifth Harmony.
United States veteran Janet Jackson was crowned a "global icon", a title previously awarded to U2, Queen, Whitney Houston and Eminem.
The former member of the band Fifth Harmony was also named best pop artist at last year's MTV Europe Music Awards. There were performances by Nicki Minaj, Halsey, and Marshmello. When the cube lifted, water poured down on her like rain.
Nigeria's 26-year-old Hauwa Ojeifo - a bold change maker who founded a movement of love, hope and support to give mental health a voice in her home country, Nigeria - was announced a joint victor of the first-ever "MTV EMA Generation Change Award".