By focusing primarily on childhood health and education, Mrs Trump's five-day swing through four African states, her first significant solo trip overseas as First Lady, is meant to cast American diplomacy in a gentler light.
The U.S. first lady touched down at mid-morning in Ghana's capital, Accra, where she was greeted by the country's first lady, Rebecca Akufo-Addo, and a young girl who offered her flowers.
School children in Ghana were made to leave the classrooms and wave Ghana and US flags at the Kotoka International Airport after her arrival with little enthusiasm.
The trip is Trump's first major solo outing overseas as first lady.
Trump also visited a baby clinic where she saw babies getting weighed as part of a nutritional program and distributed teddy bears wrapped in baby blankets.
She would also be making a donation to the facility.
She has accompanied President Donald Trump on foreign visits, but she chose Africa for her first multi-nation trip alone.
The first ladies met privately for about a half-hour at Jubilee House, Ghana's presidential palace. The first lady will also highlight the role Washington plays in helping each country, according to the U.S. Agency for International Development (USAID), which helped to coordinate the trip. Melania Trump brought a silver Chippendale tray etched with an image of the White House.