The Red Devils are now 10th in the Premier League following a draw with Wolves and defeat to West Ham in their last two league matches while they were also knocked out of the Carabao Cup last week by Championship side Derby.
United have only won one of their four matches in all competitions at Old Trafford this season - and the last time the ground hosted a Champions League game, Jose Mourinho's side were knocked out by Sevilla at the last-16 stage.
"Valencia CF can perfectly get the win against United".
Struggling Manchester United star Alexis Sanchez is believed to regret his move to Manchester United from Arsenal in January, which saw him turn down the chance to join eventual champions Manchester City, the Mirror reports.
The first sign of Manchester United fans voting with their feet have emerged.
United are perceived to be in something of a crisis, with Mourinho's team going into the match without a win in three and their manager under increasing pressure.
Perhaps more damaging still are the suggestions that United's present lethargy - statistics showed they made fewer sprints at West Ham than any other team in the Premier League last weekend - might be a deliberate attempt to undermine the manager's position.
And, though Mourinho says losing is not a problem, he says he will not accept players that aren't giving their all.
Lampard, who played under Mourinho at Chelsea, said he felt for his former boss.
"If somebody tells them "I was a football player and I didn't give my best" then I change my opinion". "You need your leaders on the pitch, the ones who are not scared to play".
"If you talk in the dressing room, that doesn't mean anything". "A club like this, a team like this, one of the most successful coaches in the world, with a huge investment".