Before proceeding to the slave castle, she visited the palace of the head chief of the area and obtained royal approval to visit the fortress after US officials presented a gift of drinks to the chiefs.
After the talks, the US First Lady has been scheduled to visit the US Embassy in Nairobi wrapping up the only closed-door engagements on her visit.
First lady Melania Trump's solo swing through Ghana, Malawi, Kenya and Egypt should come as no surprise.
The first lady was led around the facility by museum director Kwesi Essel-Blankson.
He called her "Your Excellency", and said: "We welcome you to Cape Coast and hope your short stay will be a memorable one".
While the world's media were covering the visit and Trump was testing out text messages to the nation, Trevor took to The Daily Show to welcome her to Africa.
Trump also spent about 10 minutes inside the dungeons where slaves were held before walking through the "Door of No Return" to be taken across the Atlantic Ocean.
She was also seen wearing a pair of her favorite Manolo Blahnik heels first thing in the morning - however she changed out of the sky high pumps and into the low-cost flats by the time she reached the 17th Century castle, no doubt in order to ensure she could enjoy the walking tour without worrying about her feet.
Melania Trump embraces Lillian Naa Adai Sai, 8, as she receives flowers.
"Whether it is education, drug addiction, hunger, online safety or bullying, poverty or disease, it is too often children who are hit first, and hardest, across the globe", Melania said in a brief address to a group that included the spouses of foreign leaders last week in NY, when they were in town for the United Nations General Assembly.
"With love, Melania Trump".
"It's really a tragedy", she said.
U.S. First Lady Melania Trump, right, poses with Ghana's First Lady Rebecca Akufo-Addo prior to their meeting at Jubilee House in Accra, Ghana, on October 2, 2018.
The most surprising fashion repeat however was in March 2017, when Melania wore the same $3,000 Valentino dress two days in a row - first modeling it in the Oval Office, while supporting her husband as he signed a new bill aimed at encouraging women to pursue careers in science, technology, engineering and mathematics (STEM).
President Donald Trump told reporters on the South Lawn of the White House on Tuesday that he saw television footage of her landing in Africa.