She is on her first-ever visit to Africa and her first extended solo global trip as first lady.
Daniel Afful, a local, called Trump "brave". At one intersection, hundreds of people lined up smiling and waving.
She will visit Malawi, Kenya and Egypt as well.
Some children have lessons outdoors, where they sit shoulder-to-shoulder on loose, red dirt. The facility has 22 classrooms with an average class size of approximately 106 students per class. The mother of a 12-year-old son, the crux of Trump's trip is focused on schools, hospitals and orphanages while she focuses on the wellbeing of children.
"Do you see the cameras?" she said to the boy before cradling another baby.
The first lady then visited a local children's orphanage.
Melania read a story to the same group of children with applauses as another child read a story about the "lion and the mouse". "I'm the least racist person you have ever interviewed". Trump presented Akufo-Addo with a silver tray with the White House image embossed on it and a leather case signed by Trump.
Books in English, such as "Big Bird Can Share", and "The Long Winter" by Laura Ingalls Wilder, and Judy Blume's "Just as Long As We're Together", were neatly stacked on the shelves. The school is among those in the landlocked country that receive education assistance from the U.S. Agency for International Development, including textbooks.
At the primary school, the first lady watched dozens of pupils sitting on the ground in the sun as a teacher taught on a blackboard on the side of a building. "I was heartened to spend time with the students, and was honored to donate school supplies and soccer balls", she said.
The First Lady's visit to Africa has offered up a softer side of the Trump administration, which is facing a critical vote on the nomination of Brett Kavanaugh to the Supreme Court on Friday.
Reporters with Melania Trump are not as euphoric.
After about 20 minutes of tea, the first ladies strolled onto the terrace to applause.