The game turned in its head in the 30th minute when Ronaldo was shown a straight in an off-the-ball incident with Murillo.
Ronaldo scored a staggering 451 goals in 430 appearances for Los Merengues and won two La Liga titles and four Champions League trophies. The straight red means Ronaldo would miss Juventus' trip to Manchester United, where he spent six seasons from 2003 to 2009 and blossomed into one of the world's best players, on Matchday 3 on October 23.
The sending off did little to upset the Italian champions' rhythm though as the 10 men went on to seal a 2-0 win over Valencia at the Mestalla thanks to two penalties from Miralem Pjanic.
This post will be updated.
"We all suffered together in the final stages of the game but this is a great group and we proved it again tonight".
Such questions have been replaced by bullish confidence, just in time for Juventus to launch its Champions League campaign away to Valencia.
Even Valencia coach Marcelino Garcia attempted to comfort Ronaldo as he walked off the pitch.
"But in my opinion I would give it to Cristiano Ronaldo because he has been the best throughout last season".
Bale nearly increased Madrid's lead with a close-range shot that struck the crossbar early in the second half but the Wales forward did make it 2-0 in the 58th with a well-placed low shot after a superb through ball from Luka Modric.
Ronaldo joined Juventus for 200 million dollars from Real Madrid in July.
"Last year they reached the semi-finals, nearly got to the final, we have to value the match we have played", Casemiro added.
"What I've said before is that whoever we pick will be a wonderful solution and I have nothing else to add to that", he said. But Wojciech Szczesny parried Parejo's spot kick, which was awarded after Daniele Rugani was adjudged to have elbowed Gabriel Paulista.