In Kaliningrad, they dominated possession - having more than 75% of the ball - and had 18 shots to Morocco's six.
Ramos has been football's supervillain number 1 after his role in the injury to Egypt and Liverpool star Mohamed Salah in the Champions League final in May.
It took just a few more minutes for another flashpoint to develop and Spain might have considered themselves lucky to keep 11 men on the pitch when Gerard Pique and Boutaib clashed.
"Isco always contributes with his quality and hardwork, he's good one on one, he can sneak between lines and he's hard to pin down", said Hierro, himself a Real alumnus.
Another substitute, Morocco forward Youssef En Nesyri, headed in a goal in the 81st minute to give already-eliminated Morocco hope of a victory.
Spain have finished top of Group B at the World Cup after drawing 2-2 with Morocco in Kaliningrad, and will play Russian Federation, the runners-up of Group A, in the last 16 on Sunday.
"We've shown we were able to take on two of the best teams in the world in Spain and Portugal", said the Frenchman.
Spain earn a VAR-inspired, last-gasp 2-2 draw against Morocco in order to finish at the top of Group B at the 2018 World Cup in Russian Federation.
That said, there are aspects of Spain's game that don't look right at all.
Spain have been hit and miss at this World Cup - perhaps unsurprisingly, given the turbulence surrounding the pre-tournament sacking of coach Julen Lopetegui.
The best defender on the field was a Real Madrid player, but not one who plays for Spain at global level. Even Morocco, who didn't have anything to play for... nobody is going to give you anything. "This is why we came here tonight".
A point for Spain coupled with a late equalizer for Iran against Portugal meant La Roja topped Group B by virtue of goals scored.
Three minutes after the hour mark Spain were denied the lead by a brilliant goalline clearance from Romain Saiss.
In Pique's defence, he almost made amends with a header that veered just wide, from an Isco corner, but they were grateful to Aspas for securing them first place in the group - and ensuring they avoided the risky Uruguay in the next round. "We needed them to score on us to force us to react".
Spain will now face hosts Russian Federation in Moscow on Sunday for a place in the last eight.
At the very same time in the other match, Iran tied its game against Portugal on another VAR-influenced call. You can stream all World Cup matches with fuboTV (Try for free).