An estimated 25 people, including at least three children, were killed and almost 300 injured on Sunday, officials said.
The most well-known example of the consequences of a pyroclastic flow can be found in Italy where the two Roman towns of Pompeii and Herculaneum were covered under a thick blanket of ash in 79 AD.
The conical Volcan de Fuego reaches an altitude of 3763 metres above sea level at its peak.
"Not everyone was able to get out", Consuelo Hernandez, a resident of the village of El Rodeo, told local newspaper Diario de Centroamerica, according to the Associated Press.
A view of an eruption of the Fuego volcano in Alotenango, Sacatepequez, Guatemala, 03 June 2018.
Temporary shelters have been set up for about 3,000 residents who have been evacuated.
Earlier in the day Guatemalan authorities had reportedly suspended rescue operation in the distressed area due to the foul weather conditions and decreased eruption activity.
At least seven people, including three children, were killed and almost 300 injured on Sunday in the most violent eruption of Guatemala's Fuego volcano in over four decades, officials said.
"Not everyone escaped. I think they were all buried".
Ash fell on the Guatemala City area as well as the departments of Sacatepequez, Chimaltenango and Escuintla, which are in south-central Guatemala around the volcano.
President Jimmy Morales has declared three days of national mourning. Guatemala City's La Aurora worldwide airport have been shut down due to the presence of volcanic ash on the runway, which may cause an accident.
Rescuers on Monday June 4, pulled at least 10 people alive from ash drifts and mud flows that poured down the slopes of Guatemala's erupting Volcano of Fire, but officials said at least 33 people were dead and the toll was expected to rise.
Falling ash covered the streets, cars and houses in the popular tourist destination Antigua Guatemala, located around 15 miles from the volcano, as well as in Guatemala City, where the ash clouds led to the closure on Sunday afternoon of La Aurora International Airport.
Workers and guests were evacuated from the La Reunion golf club near Antigua. The lava river was running on the other side of the volcano.
Pyroclastic flow is a dense, destructive mass of very hot ash, lava fragments, and gases ejected explosively from a volcano and typically flowing downslope at great speed.
Today, hundreds of Guatemalans were affected by Guatemala's Fuego volcano that erupted. All came from the hamlets of Los Lotes and El Rodeo, but only 13 had been identified so far because the flows that reached temperatures as high as 1,300 degrees Fahrenheit (700 Celsius) had so disfigured the bodies.
The eruption officially ended late Sunday, said Guatemala's National Institute of Seismology, Vulcanology, Meteorology and Hydrology.
The huge plumes of smoke that could be seen from various parts of the country and the ash that rained down in four of Guatemala's departments caused some alarm among residents.