His passing comes just one year after another contestant, Dr Brandon Rogers, 29, was killed in a vehicle accident weeks before his AGT audition was due to air on TV. The opera singer suffered from a health condition related to his heart.
The opera singer was best known as the champion of the third series of the USA talent show back in 2008, when he was hailed by judges Sharon Osbourne, Piers Morgan and David Hasselhoff. He'd been in heart failure and kidney failure, and he'd had liver disease.
The former insurance salesman-turned-opera singer won the 2008 competition, and the $1 million prize, after sharing with audiences - and judges David Hasselhoff, Piers Morgan and Sharon Osbourne (Jerry Springer was host) - the story of his impoverished upbringing, and love of singing.
Boyd's humble beginnings swayed the America's Got Talent fanbase to his side.
After winning AGT in 2008, he recorded his first studio album, My American Dream in 2009.
Neal E Boyd has died at the age of 42.
According to TMZ, in early 2017 Boyd blacked out while driving and got into an accident that left him and his mother badly injured. In addition to his music career, he ran for an empty seat in the Missouri House of Representatives in 2011. "[Recovery is] a very slow progress".