The violence, which came as a White House delegation and Israeli officials opened the new embassy in Jerusalem following a controversial decision from US President Donald Trump previous year, was the worst in the Israeli-Palestinian conflict since a 2014 war in Gaza.
The Israeli army said in a statement its forces were "responding with riot dispersal means and fire, and are operating according to standard operating procedures" in response to "10,000 violent rioters". Trapped by a brutally enforced sea, land and air blockade, and caught in a power struggle between Hamas and the Palestinian Authority, they live with limited electric power, little access to safe water, poor medical care and awful poverty.
"Every casualty on the border is a victim of Hamas' war crimes, every death is a result of Hamas' terror activity, and these casualties are exclusively Hamas' responsibility", he said.
"The rioters are hurling firebombs and explosive devices at the security fence and at (Israeli) troops and are burning tyres, throwing rocks and launching flaming objects with the intention of igniting fires in Israeli territory and harming (Israeli) troops". It was not clear if Israeli troops suffered any casualties.
A female Palestinian demonstrator gestures during a protest against USA embassy move to Jerusalem and ahead of the 70th anniversary of Nakba, at the Israel-Gaza border, east of Gaza City.
"Until then, no other country is allowed to move their embassy to Jerusalem and recognize it as the capital of Israel".
Peace talks aimed a finding a two-state solution to the conflict have been frozen since 2014.
"Thank you, President Trump, for having the courage to keep your promises".
"Our special bond in the envy of nations around the world", he says of US-Israel ties, noting the shared values of freedom, rights, and democracy.
The ceremony took place at what until now had been a United States consulate building in Jerusalem.
Earlier in the day, Trump tweeted that it was "a great day for Israel!"
It was the bloodiest day since a series of protests by Palestinians demanding the right to return to their ancestral homes began at the end of March.
"I think that the reluctance always before - because as has been pointed out, several previous presidents committed to move the embassy to Jerusalem - I think the hesitation has been, that it would end any prospect of an agreement between the Palestinians and the Israelis", Gates told "Face the Nation" moderator Margaret Brennan.
"Israel claims all of Jerusalem, and is doing their best to ensure it remains that way", said Aaron David Miller, a former Middle East negotiator in Republican and Democratic administrations.
The Ministry of Foreign Affairs had repeated the Government's concerns about the move of the US Embassy directly with Israel's Ambassador in the weeks before it took place.
"Today also demonstrates American leadership", adds Kushner, saying Washington has "shown the world, once again, that the United States can be trusted".
"As predicted the opening of Donald Trump's confrontational Embassy in Jerusalem has fanned flames of conflict and death".
As Israel's 70th anniversary approached - celebrated in April due to the Hebrew calendar, but the date of the country's establishment is May 14, 1948 - the violence escalated, leaving dozens dead.