But it was an even quieter night for Mohamed Salah, with the Liverpool forward lasting only 30 minutes before being forced off with a shoulder injury that now threatens his participation at the World Cup with Egypt.
Real Madrid's Cristiano leads the UCL with 15 goals to lead a talented strike force that also consists of Karim Benzima and Gareth Bale.
This year's tournament concludes with a match between reigning champions Real Madrid and English side Liverpool.
Adam Lallana replaced him but Liverpool had lost the player they could least afford to see go off.
Defender Dani Carvajal, who had been struggling in the warm-up, also left the pitch in tears moments later after injuring his ankle but it hardly redressed the balance of Salah's absence.
Bale's first was an "I-was-there" goal, one to rival Zinédine Zidane, Mario Mandžukić and any other you care to name as the best in final history. He tried to play on, telling Liverpool's medical staff that he could continue, but when he sank to the floor a couple of minutes later it was obvious there was no way back.
But a second mistake from Karius, who spilled a long shot from Bale into his net in the 83rd minute, sealed victory for Madrid and a 13th European Cup success.
But having gone into the break with a one-goal lead, Liverpool suffered a depressing second-half collapse.
After collecting a through ball from Toni Kroos, Karius attempted to throw the ball out only for Benzema to stretch a leg out and poke the ball home.
Liverpool still remain in contention for the title as the scores are level at 0-0 in the 40th minute, but Real have been handed a major boost as their opponent's main striker will not be playing any further part.