Forward Salah, who has scored 44 goals for the club this season, was hurt after being pulled down by Real captain Sergio Ramos in the 26th minute.
The Madrid side were also forced to make a change in the first half shortly after Salah went off when defender Dani Carvajal injured himself as he attempted a backheel.
The Egypt worldwide received treatment before hanging back as Liverpool took a subsequent corner.
"[He makes it] easier for the other players in midfield and up-front and also the defence, because defensively they have to think of him because he's a really risky player".
All of the focus will now be on Salah to see if he can be fit enough to play for Egypt at the World Cup this summer. "It is either the collarbone or the shoulder itself", Klopp said after Liverpool's 3-1 defeat by Real Madrid in the final in Kiev.
Cristiano Ronaldo consoles Mohamed Salah as he goes off injured in the Champions League final
A Loris Karius error, as he rolled the ball to Karim Benzema, saw Real Madrid take the lead in the 51st minute, but Liverpool hit back just four minutes later through Sadio Mane.
As Liverpool and Real Madrid geared up for the final of the Champions League, there has been conflicting reports on whether Salah will observe fast for today's match.
Started by user "Mohamed Salah Abdel-Hakeem", the petition's description reads: 'Sergio Ramos intentionally kept Mohamed Salah's arm under his armpit, causing dislocation of his shoulder.
Youth and Sports Minister Khaled Abdel Aziz said that the diagnosis for Mohamed Salah's injury is "instability in the shoulder joint ligaments", and that the estimated duration of his treatment is two weeks.
"It was a very tough night, but I'm a fighter", he said on Instagram. "It does not look good". I know (we had a great campaign) but I can't feel it.
Salah is the main man for the Pharaohs, as he helped them qualify for their first World Cup since 1990.