Physicians reported three cases in King County and two in Spokane County, the Washington State Department of Health announced Friday.
The CDC says people should not be eating or buying romaine lettuce unless they know for a fact that it is not from Yuma, AZ.
Ten people have kidney failure and 46 are in hospital.
No infections have been reported in Minnesota.
Infections have actually been connected to the E. coli O157: H7 stress and health problems have actually frequently been serious.
CDC'S Matt Wise said everyone should avoid eating romaine lettuce unless it's clearly not from the Yuma.
According to a release, the two Spokane cases happened with children under the age of 10 and neither were hospitalized.
Forty-six people out of 87 with available information (53%) have been hospitalized, including 10 who developed a type of kidney failure called hemolytic uremic syndrome.
The Yuma region provides most of the romaine sold in the US during the winter. Still, the remainder of the illnesses have not been linked to a grower and are not linked to Harrison Farms.
Given that most of the patients sickened in the outbreak had been exposed to chopped romaine, representing several subclusters, he said the FDA will be looking at dozens of farms in the Yuma growing region.
The agency also warned restaurants not to serve romaine lettuce to customers.
"We're in this transition period". However, Harris said it still wasn't clear how the lettuce was contaminated or if it was contaminated at the farm or elsewhere in the supply chain.
Call your doctor. And if you have questions about the lettuce contamination, call the state Health Department at 1-877-PA-HEALTH.
Contaminated lettuce could lead to severe gastrointestinal problems.
The last large E. coli outbreak like this involved spinach grown in California in 2016.
Stic Harris, DVM, MPH, director of the Food and Drug Administration (FDA) Coordinated Outbreak Response and Evaluation (CORE), said whole-head romaine linked to illnesses in Alaska, which occurred in eight people at a correctional facility, came from Harrison Farms of Yuma, Ariz. Though it is more common with children, up to 15 percent. CDC data suggest that leafy greens cause roughly one-fifth of all food-borne illnesses.
USA authorities have identified one farm as the sole source of romaine lettuce that affected consumers in Alaska, but there is no common link to other cases other than that the product was grown in Yuma, Arizona.