It is not surprising, then, that this past weekend's events seem like a watershed moment.
Iran's involvement in Syria includes the deployment of Iran-backed forces near the Israeli-occupied Golan Heights, which has alarmed Tel Aviv. Israel is not the only country to have military aircraft shot down by enemy fire in Syria recently.
Meanwhile, State Department spokeswoman Heather Nauert said, "The United States is deeply concerned about today's escalation of violence over Israel's border and strongly supports Israel's sovereign right to defend itself". How much can the US or Russians help, remains an open question.
According to Israel, the drone is a reverse-engineered copy of the stealthy U.S. RQ-170 Sentinel UAV lost over Iran in 2011.
Furthermore, it would appear that President Assad is not going to be removed from power anytime soon.
An Israeli military spokesman said Israel did not seek escalation in the region, calling its action a defensive effort triggered by an Iranian act of aggression.
The FDD is an annex of the Israeli lobby and a charter member of the War Party. And Iran, to plant more firepower there.
Our orders have been cut.
Saudi Arabia, Qatar and Jordan all use various Sunni rebels to fight the pro-Iranian, pro-Shiite regime forces, and Israel is using the long arm of its air force.
"God willing, they will see more surprises whenever they try to attack Syria", he added. What guarantees the security and stability of countries that are surrounded with war is security, and an end to expansive political projects.
Indeed, why would Iran, which, with Assad, Russia and Hezbollah, is among the victors in Syria's six-year civil war, wish to reignite the bloodletting and bring Israeli and US firepower in on the other side? "We must embark on a diplomatic and economic campaign to stop Iran in Syria and throughout the region".
But as IS shrinks, the estimated 2,000 US troops stationed in Syria find themselves caught in a highly unpredictable and shifting battlefield, as demonstrated by an unexpected attack by pro-Assad fighters on USA -backed forces who were accompanied by USA advisers in Deir el-Zour. It appears that USA advisers were working there.
Turkey has sent in troops, lobbed artillery from across the border and used airstrikes in its operation in the Afrin enclave to rout the Syrian Kurdish militia, known as the People's Defense Units or the YPG.
The U.S. and Turkey, allies for six decades, with the largest armies in North Atlantic Treaty Organisation, may soon be staring down each other's gun barrels.
Of course, the bloody, almost 7-year-old Syrian civil war is probably far from over - not to mention that other major powers such as Russia, Turkey, Saudi Arabia and the United States have a say in Syria's future.
Regarding US-Egypt relations, Tillerson said: "We agreed we would continue our close cooperation on counterterrorism measures". And we have a strategic interest in not losing Turkey as an ally. The ambassador called such actions "cynical blackmail". What would victory look like?
The weekend's events began with Iran launching an unmanned aerial vehicle (UAV), more commonly known as a drone, from Syria and into Israel on the morning of February 10. If Israel were a model democracy, it would not promote civil unrest in other countries, rather it would grant all Palestinians full civil rights, thereby resolving the unrest in its own country.