But if Sunday's draw at Palace was the first sign of a City wobble, the demands of a testing January will tell us whether it is enough to knock them off their stride or merely prove to be nothing more than a brief stumble on their march to record-breaking glory.
"The Premier League is a very physical league and the referees must take care of the players".
"Not just the best players".
"I haven't spoken to the FA (Football Association) about it".
"People are talking about diving and about how they [the referees] need to focus on the diving, that's okay".
"I know the contact is allowed here more than any other country, but there is a limit".
The loss of Jesus could strengthen City's resolve to sign Arsenal forward Alexis Sanchez during the January transfer window, although Guardiola played down the possibility of a move for the Chile global.
Speaking after the Arsenal and Crystal Palace's recent league match Henry said that there is a clear indication of a split in the dressing room after Sanchez celebrated his goal alone with his team mates refusing to join him. Jesus faces up to two months out with suspected knee ligament damage, while De Bruyne's injury, not believed to be as serious as his teammate's, will nearly certainly force the Belgian to miss the Watford game. "But my feeling now is that he's an Arsenal player and he will be".
Former Aston Villa and Holland midfielder George Boateng believes Sanchez could inspire City if he makes the move from the Emirates to the Etihad.
The Chilean global has six months left on his contract and has decided against signing a new deal at the Emirates.
"In the internal meetings we are going to decide what is best. You'd rather take the points that he can give Arsenal than to take the money".
It is all relative, of course, but dropped points and worrying injuries count as a mini-crisis for Manchester City these days. But not this Watford side.