Heavily armed police stand guard near the scene after a motorist drove onto a busy bicycle path near the World Trade Center memorial and struck several people.
The Daily Mail UK reported that the man driving the truck screamed "Allahu Akbar" while driving down a bike path, crushing several along the way.
New York Governor Andrew Cuomo called it a "lone wolf" attack, and authorities have said there is no ongoing threat or evidence of a wider plot.
To the editor: Tuesday's terror attack in NY was another despicable and vile act of cowardice at the hands of a deranged lunatic, and it is to be condemned in the strongest terms.
Tom Gay, a school photographer, was on Warren Street and heard people saying there was an accident.
The author quickly addresses the fact that Sayfullo Saipov "was said to have cried out "Allahu akbar" before he was shot by a police officer", and recounts the use of the phrase during the 2015 Charlie Hebdo attacks, before citing a number of examples in which the phrase is used in a harmless context. "He has a gun!" He said he then heard seven to eight shots and then police pointing a gun at a man kneeling on the pavement. "When I ran up the bridge, I saw this dude with two guns". "Everybody starts running." Saipov's bloody, 17-block trail of terror began at 3:05 p.m., when he turned onto the bike path at West Houston Street in a Home Depot flatbed pickup truck he'd rented in Passaic, NJ, police sources said. He said the truck had also collided with a small school bus and one other vehicle. The suspect hopped out of the truck with what looked like a gun in each hand, prompting police to fire. Allow me to clarify: You don't have to dip your bullets in pig blood to kill us.
Condemning the attack, USA president Donald Trump said "we must not allow ISIS to return".
President Trump been briefed on the incident according to White House press secretary Sarah Sanders.
NY and other cities around the globe have been on high alert against attacks by extremists in vehicles.
But the phrase - to many Muslims' distress - has also been seized on by jihadists who claim that Islam justifies their attacks on innocent civilians in the name of God.