The comments represented a shift in strategy for the White House, which previously tried to keep its distance from the controversy sparked by a Washington Post report detailing accusations by four women that Mr Moore pursued them when they were teenagers and he was in his 30s.
Trump himself has stood by Moore in the wake of the allegations. "But you mentioned the economy, and while I think it's foolish to give him all the credit for the good economy, it would also be absolutely unfair not to give him a significant amount of credit for the economy".
The race had otherwise been seen as a safe bet for Republicans, but some polls show Moore now losing. Lindsey Graham said, "If you can't be in a mall, you shouldn't be in the Senate". Trump has repeatedly told his aides he does not believe Moore would ever quit.
The Left was always going to come at Alabama Republican Roy Moore with everything they had, a conservative author told Laura Ingraham Wednesday night on "The Ingraham Angle".
But something deeper has been consuming Trump.
A total of nine women have claimed that Moore a former Republican judge fondled and otherwise pursued them in Alabama when they were teenagers
Moore has denied the accusations. The Times noted that Trump verified the accuracy of the tape and apologized for his recorded comments when they were first unearthed in October 2016. When a group of senators gathered with the president in the White House last week to discuss the tax overhaul, it took little to get Trump onto the topic of Moore - and he immediately offered the same it-was-40-years-ago defense, according to officials at the meeting. He's also denied the allegation of sexual assault.
Absent action from Trump, party leaders have explored - and abandoned - a number of ways to derail Moore.
The Republican National Committee and the National Republican Senatorial Committee are both pulling their support for Mr Moore's campaign ahead of the December 12 special election that he is running for.
Moore has been accused of sexual contact by multiple women, including Leigh Corfman, who alleges that Moore tried to initiate a sexual encounter with her when she was 14.
"All you can do is identify a way out of the mess, and if people don't want to follow it, that's on them", said Josh Holmes, one of McConnell's closest political advisers.