In particular, Loftus-Cheek shone on his worldwide debut, dominating the vastly more experienced Mesut Ozil for large sections of the game.
Southgate is without a number of first-team regulars for the games against Germany and Brazil, with the likes of Kane, Henderson, Sterling and Alli all unavailable due to injury.
The Chelsea midfielder, who is on loan at Crystal Palace for the season, was named man of the match for England's 0-0 draw with Germany as he played behind Jamie Vardy and fellow debutant Tammy Abraham.
'He's a player I've watched do that from Under-16 level, and despite his size and his appearance and the way he plays, he's not a hugely confident at times, ' said Southgate.
"Tonight it took him 10 minutes to have a look around and think "Alright okay, I can do this".
"It seemed as if okay, there's loads of pull outs and it's a bit messy, but actually it was really tight and I think the performance without getting too carried away was a really encouraging one". With the age in the squad, it was good for us young players.
England's best chance of the half came when Abraham's shot on the turn was deflected just a whisker wide off Antonio Rudiger. There's been an energy about the group.
The 21-year-old England worldwide is also a regular in the England starting lineup when he is fit.
'I was hoping to bring him in last month but he had an injury.
It was only one game, against opponents who could easily have moved up a gear, but Ruben Loftus-Cheek's performance against the world champions gave a glimmer of hope for the future.
Norwich goalkeeper Angus Gunn, on loan from Manchester City, will join up with the senior squad as cover for Jack Butland, who broke his finger in training on Thursday.