Ryan was 26 of 35 for 317 yards, while Sanu remained ideal in his career when throwing the ball.
Julio Jones is so good and so vital to the Falcons that, with Atlanta leading by touchdowns in the third quarter against the Ryan Fitzpatrick-led Buccaneers, his presence on the field triggered an internal alarm of sorts.
Per NFL research, Sanu (6-for-6, 228 yards, 3 TDs) has a flawless 158.3 passer rating in his career.
With 7:26 left in the second quarter, Jones caught another touchdown pass - this one a 25-yarder from Ryan.
Sanu's previous touchdown passes came in 2012 and 2014, respectively, when he played for the Bengals.
In a 5:10 span in the second quarter on Sunday, Jones added two touchdowns to his total.
Julio Jones stuns as Falcons win over the Bucs
But Keanu Neal battled down Fitzpatrick's pass on fourth-and-1 at the Atlanta 18 with just over 7 minutes remaining, and the Falcons drove for a clinching touchdown on Tevin Coleman's 14-yard run with just under 2 minutes to go.
It's also not a coincidence the offensive clicking coincides with Jones having one of the best games of his illustrious career: 12 catches for 253 yards and two touchdowns on 15 targets - all season highs.
Coleman, filling in for again for injured Devonta Freeman, rushed for 97 yards and two TDs. In addition to QB Jameis Winston (shoulder), the Bucs started the game without DE Robert Ayers (concussion), CB Vernon Hargreaves (hamstring) and G Evan Smith (concussion).
Flying back from Seattle after their second consecutive win, the Falcons beat the Buccaneers Sunday, 34-20, with as diversified an offense attack as they've featured under rookie coordinator Steve Sarikisian. In what was originally thought to be a huge NFC South showdown, the Bucs ill be looking to keep their slim playoff hopes alive by beating the Dirty Birds in Mercedes-Benz Stadium.
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