De la Huerta has been locked in a legal battle with Lionsgate over her work in the movie Nurse 3D.
Boyce said detectives found the "Boardwalk Empire" actress' story believable and that two people corroborated portions of her account.
Robert Boyce said the alleged victim "put forth a credible and detailed narrative".
"We have an actual case here".
Vanity Fair reported on Friday, November 3, de la Huerta's allegations have launched a new NYPD investigation and NYPD officer Nicholas DiGaudio believes they have enough evidence to move forward with an arrest.
"Immediately when we got inside the house, he started to kiss me and I kind of brushed [him] away", de la Huerta said.
Weinstein insisted they have drinks inside her apartment and that's where the alleged assault happened, she said.
Almost two months later, de la Huerta said Weinstein showed up in the lobby of her apartment one night.
"As this is an active investigation", the statement continues, "we will not be commenting further".
The update comes shortly after Beverly Hills authorities became the fourth police department to launch a probe into claims made against the movie mogul.
She told CBS that she had been drinking that night and was in no state to agree to having sex.
Gwyneth Paltrow and Angelina Jolie are among the actresses to accuse Weinstein of sexual harassment, while Rose McGowan said he raped her.
Weinstein's representative, Sallie Hofmeister, says the 65-year-old Oscar victor denies any allegations of non-consensual sex.
Is there enough evidence for prosecutors to file charges against Weinstein?
Manhattan district attorney's spokeswoman Joan Vollero says a senior sex crimes prosecutor has been assigned to the investigation, which is being conducted along with NY police.
He said the NYPD was working on the case with the Manhattan district attorney's office.