The second explosion, heard miles away, came just minutes after people and rescue workers had rushed to evacuate the dead and wounded in the relatively smaller first blast.
Shahid Khan, a local official in Parachinar, said Saturday that numerous victims of the attacks are in critical condition. An assistant sub-inspector was among those killed in the attack, said Superintendent of Police Asif Ahmad.
Wasim Beg, a spokesman at a government hospital, said the death toll from the bombing had risen to 12 throughout the morning and some of the wounded remained in critical condition.
Three others were killed in Parachinar hours later when security officers opened fire to disperse demonstrators who gathered to condemn the attacks and demand authorities provide better security.
"A total of 216 people were injured in the twin blasts".
The first explosion in the city of Quetta killed at least 13 people.
Pakistani Prime Minister Nawaz Sharif condemned the terrorist attacks, saying that those responsible will be taken to task.
Separately in the evening, three militants riding on two motorbikes killed four policemen in a restaurant in Karachi.
A faction of Pakistan-based sectarian militants Lashkar-e-Jhangvi today claimed responsibility for twin bombs that hit a market in the northwestern town of Parachinar, killing at least 50 people ahead of the holiday marking the end of Ramadan.
The army has also been fighting in mineral-rich Balochistan province, since 2004, with hundreds of soldiers and militants killed. The army sent two helicopters from Peshawar to take part in the rescue efforts.
The newspaper added that while no group has yet claimed responsibility for the Parachinar blasts, Jamaat-ul-Ahrar - a splinter group of the banned Tehreek-i-Taliban Pakistan and Isis has reportedly claimed responsibility for the Quetta attack.
The first blast was used as a decoy to lure more people to the site for the second attack. The security forces cordoned off the entire area and started the search operation.
Pakistan is in the middle of a widening military operation to oust militants from key areas. TV footage showed panicked people rushing to safety following the Parachinar market bombings.
The funeral prayers of the seven policemen were later offered at Police Lines.
In March, a vehicle bomb exploded near a Shiite mosque in Parachinar, killing 24 people, mostly Shiites.