Kvitova, who was playing in her first tournament since she was injured in a knife attack at her home in December, threw her racket in frustration after she double-faulted on match point.
Kvitova and Mattek-Sands shared a long embrace at the net, and the American said: "She's an inspiration, actually".
Get daily prep sports headlines from the Gwinnett Daily Post staff delivered to your email. She underwent over three hours of surgery to fix tendons and nerves in her fingers and was told not to put weight on her left hand for three months. I'm disappointed, for sure. "This year, the expectations are much bigger, especially in the big tournaments and the Grand Slams", added Kerber, who won her first major at the Australian Open in 2016.
I will really enjoy the time to be there.
The German dropped serve in the next game, with Makarova hitting another four clean forehand winners to consolidate her hold on the match.
"It's weird", said Kvitova.
The American then came from 3-0 down to win the breaker, a thumping backhand return victor earning a set point that was converted with an unreturned serve, but left the court for treatment after moving ahead. "The fairytale ended. Now, in upcoming weeks, I think it will be business as usual". World No. 40 in the singles, Makarova is a former French Open champion - in the doubles, winning the title in 2013 with longtime partner Elena Vesnina. But I really fought.
"Of course I'm disappointed that the clay court season was not so good".
"I think that, you know, my game still suits the grass, and I will do my best to be there".
Thats the beauty of our sport right now: Anybody can win and everybodys really good, said Shelby Rogers, an American who beat Marina Erakovic of New Zealand 7-6 (4), 6-4 on a steamy Sunday when the temperature touched 90 degrees (32 Celsius).
Elsewhere in the women's draw Wednesday, Ekaterina Makarova, who upset top-seeded Angelique Kerber in the first round, could not follow up on her great performance and exited in the second round.
German world number one Kerber, the reigning US Open champion, dropped serve six times on her way to a 6-2, 6-2 defeat to Russian Federation s Ekaterina Makarova.
The German will be happy to leave Roland Garros behind, and hope to rediscover a game in which several cylinders are misfiring in time for Wimbledon, where she finished runner-up a year ago. Her hand is still not back at full strength, but she has assured her doctors that she will withdraw if pain emerges after playing.
Kerber has never made it past the quarterfinals at the French Open.