A crash crew from Wright-Patterson Air Force Base, along with heavy rescue equipment, was dispatched.
No injuries have been reported but emergency crews are working to extricate two people from the plane.
A statement Friday from the U.S. Air Force Thunderbirds said the F-16D Fighting Falcon was conducting a "single-ship familiarization" and had a "mishap".
A tweet from the Thunderbirds indicated the incident occurred while the plane was landing at 12:20 p.m.
One of the famed Air Force Thunderbirds that was practicing for an air show at an airport in OH had a "mishap upon landing", Friday, Fox News can confirm.
The pilot safely ejected himself from the plane, and was treated at an area hospital, according to officials.
The U.S. Air Force Thunderbirds are the headlining act for the annual Dayton Air Show, which is scheduled for Saturday and Sunday. One has been extricated and crews are now working to extricate the other. Reed said there was no immediate report of any injuries or fuel leaks.
The news organization said an eyewitness saw a Thunderbird F-16 coming in for landing, had slipped and wound up on its top.
We will have more updates on WFLA.com when more facts are released.