It is believed that over 50 firefighters are tackling the blade which broke out on Turin Street at approximately 4:30pm this afternoon.
A flat on the third floor and roof is alight, the fire service said in a statement.
More than 40 firefighters are on the scene of the blaze in Bethnal Green, with footage from the scene showing flames pouring from windows of a four storey block.
It comes not long after at least 79 people lost thier lives in a blaze at London's Grenfell Tower, and the same day hundreds were forced from thier homes after safety inspections.
The man is being treated for smoke inhalation.
Residents of a block of flats in east London have been evacuated from the building because of a fire.
A huge blaze has broken out at a block of flats in east London.
The fire has destroyed a flat and the entire building's roof.
Labour MP for Bethnal Green and Bow, Rushanara Ali, said residents were anxious "given what happened in Grenfell Tower".
The cause of the fire is not yet known.