Born to an Indian immigrant father and an Irish mother, Varadkar is now serving as Ireland's Minister for Social Protection.
Leo Varadkar, the 38-year-old Minister for Social Protection, was elected leader of the ruling Fine Gael party on Friday. Then the minister of health, he joined several other openly gay Irish politicians in backing the Marriage Equality Bill allowing same-sex couples to Wednesday.
Speaking after the result was announced, Varadkar said he was delighted, humbled and honoured to win.
Irish PM Enda Kenny resigned as head of the governing Fine Gael party, putting Varadkar and Housing Minister Simon Coveney in the leadership race.
Varadkar said his father traveled 5000 miles to reach Ireland, but never imagined that his son would grow up to lead the nation. I am not a half- Indian politician, or a doctor politician or a gay politician for that matter. In addition to being a Prime Minister for 6 years since 2011.
Varadkar is expected to officially take up the role as Taoiseach on June 13 after a formal confirmation from parliamentary members.
Varadkar's father is a doctor from Mumbai and his mother is an Irish nurse. "He's a once-in-a-generation politician", said Fine Gael Member of Parliament Jim Daly, echoing the comments of most of his colleagues who have placed high hopes in Varadkar.
The votes of the parliamentary party will be counted last but Mr Varadkar had secured the backing of 46 of the party's 73 lawmakers ahead of the vote compared with 21 who say they would vote for Mr Coveney. It's just part of who I am'.
Serving as Minister of Health, he came out on Irish national radio in unison with other openly gay leaders to support the Marriage Equality Bill. Now serving as the Minister for Social Protection in Ireland, he is a doctor by profession and started his political career in medical school.