Jack Nowell will come in on the right wing with Jack Clifford winning his ninth cap from the back-row.
England had to rally from behind twice against France, scoring a 70th-minute try to win 19-16. Tom Wood will also play his part later in the game off the bench as a finisher.
The move will be welcomed by rugby traditionalists who have long insisted that adapting to potentially adverse weather conditions is one of the key aspects of the game.
Henry Slade is among the 24 players retained by Jones, in an updated squad announced by team management, and is likely to remain with England as travelling reserve.
England: Mike Brown, Jack Nowell, Jonathan Joseph, Owen Farrell, Elliot Daly, George Ford, Ben Youngs; Joe Marler, Dylan Hartley (captain), Dan Cole, Joe Launchbury, Courtney Lawes, Maro Itoje, Jack Clifford, Nathan Hughes.
That scenario would mean England's trio would possess only four global back-row starts between them, a paltry number compared to the 147 held by Wales' Sam Warburton, Justin Tipuric and Toby Faletau.
Kingston, the Quins director of rugby, said: "Jack has played in front of big crowds and while it is a different arena, he is a quality act and will make sure he has prepared meticulously".
England won in Cardiff two years ago, but some players will still bear the scars of 2013 when they travelled seeking a Grand Slam, but were hammered 30-3. They hoped to make England freeze, but Chris Robshaw got into a standoff with officials and refused to leave the tunnel until Wales came out at the same time.
"I can't see that just because we drive down the M4 they get an advantage", said the England boss. "But the rugby has to be the focus and hopefully we can do the occasion justice". He had a superb game against them in May and knows what to expect from Wales.
"They have got exciting backs".
Some Twitter users disagreed with the decision to drop the video, saying they found it amusing.
Others argued that rugby is an "open air sport" and should be played in such conditions. Maro Itoje (Saracens) 7.
"We are just going to concentrate on ourselves and put a big focus on ourselves". We are going to concentrate on ourselves - that's where the main focus is.
The Australian took over after England's first-round exit on home soil at the 2015 World Cup, where a concluding win over minnows Uruguay was not enough to overturn the impact of pool defeats by Wales and Australia.