On Thursday, Rosie changed her Twitter profile photo to an image of her face Photoshopped onto the body of Trump's controversial advisor Steve Bannon.
Melissa McCarthy's hilarious portrayal of White House Press Secretary Sean Spicer last week received kudos and praise from viewers who were thoroughly impressed and entertained.
Fortunately we only have to wait till tomorrow to see if Saturday Night Live indeed brings in O'Donnell; McCarthy's appearance last week was unannounced.
O'Donnell's latest Twitter picture suggests she could be playing Bannon on this weekend's episode of Saturday Night Live.
The big one, naturally, is Rosie O'Donnell, whose "feud" with Trump has spanned decades at this point.
Alec Baldwin, of course, is SNL's resident Trump impersonator.
The former "The View" co-star has always been a vocal critic of Trump.
"Trump, @Rosie, was upset that a staffer was played by a woman, and you do a great impression of him".
When another Twitter user named Bannon, O'Donnell tweeted that she was "available".
The catalyst of her Bannon look came Monday after the former "The View" host responded to fan suggestions that she should spoof the adviser on "SNL".
Now, amid social media chatter calling for more political drag on "SNL", longtime Trump enemy Rosie O'Donnell is ready to push some gender buttons.
Spicer told Extra he found the bit "really amusing", but a source close to Mr. Prez said he was not as amused. (Trump has denied this on Twitter.) So, doesn't it just make sense to have O'Donnell playing the puppet master?
O'Donnell, however, has stood her ground.
Rosie tweeted back that she was "here to serve".
So far, "SNL" has portrayed Bannon as the Grim Reaper.