The Patriots have a rookie 3rd round pick at left guard, an undrafted sophomore at center, and a 4th round sophomore at right guard that missed time this preseason with a broken hand.
As of late last night, the quarterback situation remained up in the air.
It was the first loss of the season for New England (3-1), which was playing its final game before Brady returns from his four-game "Deflategate" suspension.
On the offense, Buffalo is averaging 23.7 points and 283.3 yards per game.
Having gone (0-2) against the Patriots a season ago losing both matchups by one score a piece the Bills looks to enact some revenge on Bill Belichick and company in perhaps their best opportunity they have had in years.
Sep 18, 2016; Foxborough, MA, USA; New England Patriots quarterback Jimmy Garoppolo (10) is forced out of the pocket by Miami Dolphins defensive end Cameron Wake (91) during the second quarter at Gillette Stadium.
Brissett started against the Houston Texans in Week 3 but sustained an injury of his own - to his throwing thumb - in the 27-0 win on September 22.
SLOW GOING: The Patriots' offense was anemic in the opening quarter, failing to get a first down while managing 20 total yards.
The Patriots will look to bounce back next Sunday when they travel to Cleveland.
The Patriots have had almost ten days to prepare for Sunday, after playing the Thursday night game during Week 3. The Buffalo Bills are the last obstacle Bill Belichick needs to navigate before Brady's return. It's allowing Tyrod Taylor and LeSean McCoy to effectively control the game much better, which opens things up for the defense - something Rex Ryan is excellent at controlling. "They've got a good front, secondary's good". The defense will not be as lucky this week, as the Patriots will not be throwing deep passes like Palmer last week.
The production is occurring despite Buffalo missing several key players.
- The Pats finished the month of September undefeated.
The Bills are looking to surprise the National Football League nation once again after their dominant 33-18 home victory over the Arizona Cardinals a week ago. When Brown signed in the offseason after four years with the Titans, it was thought he would be a third-down linebacker and a special-teams player. Leggarrette Blount led in rushing with 105 yards and two touchdowns in 24 attempts while Brissett added 488 yards and a touchdown in eight carries.
"We just have to come together as a team, you know, short week, have to get ready for a good team to come in here and for a hard battle", he said after practice.
The New England Patriots may be winning so far, but they have had it tough when it comes to keeping quarterbacks available.
Our sources say that after paying roughly $1.7 billion in cash to buy the Bills, ownership's last concern is over saving $22 million if they decide Ryan isn't the guy they hoped.