Standing in for Palmer, who suffered a concussion on Sunday against the Los Angeles Rams, quarterback Drew Stanton made his first National Football League start since 2014 and threw two touchdown passes to wide receiver Larry Fitzgerald.
Arizona (2-3) forced three turnovers and turned them into two touchdowns and a field goal. 49ers quarterback Blaine Gabbert was pressured 25 times and sacked nine times. Completions of 13 yards, 17 yards and 24 yards moved the offense into the red zone.
The chants started again after Gabbert threw his second interception. Jeremy Kerley chipped in with eight catches for 102 yards and a touchdown. He did, though, drop a pass. They have yet to score a point in the first quarter this season.
On Thursday, after the 49ers had crawled ahead 7-0, Gabbert had a pass deflected at the line for a momentum-turning turnover that immediately led to the Cardinals' tying touchdown. Gabbert had a third-down throw tipped at the line of scrimmage by Chandler Jones and intercepted by Calais Campbell.
Stanton was also helped by the fact that receiver LARRY FITZGERALD had one of his better games of the season, with his two pivotal touchdowns that were included in his 6 catch for 81 yards night.
Backup guard Earl Watford and backup tackle John Wetzel filled in, and Arians was impressed with their play. San Francisco held Arizona's offense to seven first downs and 1-of-8 on third down. Sure, there's special teams issues and injuries on defense, but the biggest problem has been quarterback Carson Palmer. The defense doesn't start the second half. San Francisco initially got a stop, but a running into the kicker penalty gave the Cardinals a fresh set of downs.
On the opening kick of the second half, Arizona set the tempo, forcing and recovering a fumble. He has become the first Cardinals player ever to register a sack in each of his first five games.
He put the Cardinals on his back and carried them to a win. There's your story of the game.
According to Pro Football Focus, Peterson has only given up 89 yards all season, the least of any cornerback who has started four games or more this year.
With 1:52 left in the game the 49ers cut the Cardinals lead to 31-21. Chief among San Fran's problem is the loss for the season of their best defensive player and inspirational leader NaVorro Bowman last Sunday to a torn Achilles.
The Arizona Cardinals' pass rush was expected to get a big boost this season, but that wasn't supposed to come from a returning member of the team.
Hyde finished the game with 22 carries for 78 yards and the score.
After the game, Beckham, who was limited to three catches for a career-low 23 yards, complained that he has been targeted by the league's officials, drawing flags and fines for nearly anything he does.
But it was the only sustained drive of the first half for either team.
QUICK TURNAROUND: The game changed in a span of less than 4 minutes starting late in the second quarter. This is the first time in Kerley's career that he's found the end zone in back-to-back contests.
Stanton did not generate much offense in the absence of Palmer, struggling with a concussion, and he had 11 of his 27 passes for 124 yards aerial gains.
Gabbert completed 18 of 31 passes for 162 yards and one touchdown with two interceptions for the 49ers, who lost their fourth straight.