During Everybody Loves Raymond's nine-year run, she won the outstanding supporting actress in a comedy series award at the Emmys four times - and was nominated a further three times.
TMZ report that she passed on Sunday in Los Angeles.
But she was perhaps best known for her role as Marie Barone on the hit CBS series "Everybody Loves Raymond".
She also appeared in films, including "National Lampoon's Christmas Vacation", "Ladies on Sweet Street", "My Giant" and "Madea's Witness Protection". She stayed with the show through 1987.
The creator of "Everybody Loves Raymond" took to Twitter to remember the actress. Roberts' second husband, William Goyen, died in 1983.
Roberts was a five-time Emmy Award victor with a career that spanned six decades.
Doris Roberts, of 'Everybody Loves Raymond,' dead at 90, TMZ reports
My wonderful TV mother-in-law and ELR nemesis Doris Roberts was a consummate professional from whom I learned so much. We spoke at length about ageism in Hollywod & I'm proud to say I think she overcame it.
The actress began her stage career on Broadway in the 1950s, amassing credits that eventually included Neil Simon's "The Last of the Red Hot Lovers" and Terrence McNally's "Bad Habits".
Doris Roberts as Shimmy in the CBS PLAYHOUSE movie, Shadow Game. Life, Laughs, and Lasagna, a memoir with recipes, in 2005.
"I'm not a bull artist", Roberts told Parade magazine.
Roberts also wrote a cookbook in 2005 aptly titled Are You Hungry, Dear?
Roberts, then 79, fretted openly about what she would do next. Roberts' son, Michael Cannata, informed Daily about his mother's demise.
Her cause of death has not been made public, but a statement said the Missouri-born actress had been healthy and active.